ID   MDCKII-LE
AC   CVCL_VR40
SY   MDCKII-Low Efflux; RRCK; Ralph Russ Canine Kidney
DR   ChEMBL-Cells; CHEMBL4295481
DR   ChEMBL-Targets; CHEMBL4296468
DR   PubChem_Cell_line; CVCL_VR40
DR   Wikidata; Q95987829
RX   PubMed=21766308;
CC   Characteristics: Compared to the parent cell line, has a lower expression of endogenous ABCB1/MDR1.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Cocker Spaniel.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_0424 ! MDCK-II
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 13-11-18; Last updated: 05-10-23; Version: 7
//
RX   PubMed=21766308; DOI=10.1002/jps.22674;
RA   Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X.,
RA   Gebhard D.F., Lai Y.-R., Federico J.J. III, Davidson R.E., Smith R.,
RA   Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S.,
RA   Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D.;
RT   "Development of a new permeability assay using low-efflux MDCKII
RT   cells.";
RL   J. Pharm. Sci. 100:4974-4985(2011).
//