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Cellosaurus MDA-MB-231 VIM RFP (CVCL_VR67)

[Text version]

Cell line name MDA-MB-231 VIM RFP
Accession CVCL_VR67
Resource Identification Initiative To cite this cell line use: MDA-MB-231 VIM RFP (RRID:CVCL_VR67)
Comments Characteristics: A red fluorescent protein (RFP) tag was added to the C-terminal of the VIM gene by CRISPR/Cas9. Allows to monitor the epithelial-to-mesenchymal transition (EMT) status of cells in vitro by monitoring RFP expression.
Transfected with: UniProtKB; Q9U6Y8; RFP.
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (ClinVar=VCV000040364) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (ClinVar=VCV000376657) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO12,13
D5S81812
D7S8208,9
D13S31713
D16S53912
TH017,9.3
TPOX8,9
vWA15,18

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Cross-references
Cell line collections ATCC; HTB-26MET
Other Wikidata; Q95987359
Entry history
Entry creation25-Feb-2019
Last entry update02-Jul-2020
Version number3