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Cellosaurus GTL16S5 (CVCL_VS69)

[Text version]
Cell line name GTL16S5
Synonyms GTL16 S5
Accession CVCL_VS69
Resource Identification Initiative To cite this cell line use: GTL16S5 (RRID:CVCL_VS69)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:91425; 2-[4-[3-(6-quinolinylmethyl)-5-triazolo[4,5-b]pyrazinyl]-1-pyrazolyl]ethanol (PF-04217903).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7668 (GTL-16)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=22745804; DOI=10.1371/journal.pone.0039653
Lee N.V., Lira M.E., Pavlicek A., Ye J.-J., Buckman D., Bagrodia S., Srinivasa S.P., Zhao Y.-J., Aparicio S., Rejto P.A., Christensen J.G., Ching K.A.
A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through MAPK activation.
PLoS ONE 7:E39653-E39653(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VS69
Encyclopedic resources Wikidata; Q93935419
Entry history
Entry creation25-Feb-2019
Last entry update05-Oct-2023
Version number8