Home  |  Contact

Cellosaurus CHM1hTERT (CVCL_VU11)

Cell line name CHM1hTERT
Synonyms CHM1htert; CHM1
Accession CVCL_VU11
Resource Identification Initiative To cite this cell line use: CHM1hTERT (RRID:CVCL_VU11)
Comments Characteristics: Has a completely homozygous genome, thus representing a functionally haploid genome.
Transfected with: HGNC; 11730; TERT.
Omics: Genome sequenced.
Anecdotal: Because of its homozygous genome it is being used to build/correct new generation of human genome assemblies.
Disease Hydatidiform mole (NCIt: C3110)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Fetus
Category Telomerase immortalized cell line
Web pages https://www.diark.org/diark/species_list/Homo_sapiens_CHM1htert
http://www.bio-itworld.com/2014/6/30/hunt-new-human-reference-genome.html
Publications

PubMed=25373144; DOI=10.1101/gr.180893.114
Steinberg K.M., Schneider V.A., Graves-Lindsay T.A., Fulton R.S., Agarwala R., Huddleston J., Shiryev S.A., Morgulis A., Surti U., Warren W.C., Church D.M., Eichler E.E., Wilson R.K.
Single haplotype assembly of the human genome from a hydatidiform mole.
Genome Res. 24:2066-2076(2014)

PubMed=27895111; DOI=10.1101/gr.214007.116
Huddleston J., Chaisson M.J.P., Steinberg K.M., Warren W., Hoekzema K., Gordon D., Graves-Lindsay T.A., Munson K.M., Kronenberg Z.N., Vives L., Peluso P., Boitano M., Chin C.-S., Korlach J., Wilson R.K., Eichler E.E.
Discovery and genotyping of structural variation from long-read haploid genome sequence data.
Genome Res. 27:677-685(2017)

PubMed=28396521; DOI=10.1101/gr.213611.116
Schneider V.A., Graves-Lindsay T.A., Howe K., Bouk N., Chen H.-C., Kitts P.A., Murphy T.D., Pruitt K.D., Thibaud-Nissen F., Albracht D., Fulton R.S., Kremitzki M., Magrini V., Markovic C., McGrath S., Steinberg K.M., Auger K., Chow W., Collins J., Harden G., Hubbard T.J.P., Pelan S., Simpson J.T., Threadgold G., Torrance J., Wood J.M., Clarke L., Koren S., Boitano M., Peluso P., Li H., Chin C.-S., Phillippy A.M., Durbin R., Wilson R.K., Flicek P., Eichler E.E., Church D.M.
Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly.
Genome Res. 27:849-864(2017)

PubMed=30013044; DOI=10.1038/s41592-018-0054-7
Li H., Bloom J.M., Farjoun Y., Fleharty M., Gauthier L., Neale B.M., MacArthur D.G.
A synthetic-diploid benchmark for accurate variant-calling evaluation.
Nat. Methods 15:595-597(2018)

Cross-references
Biological sample resources BioSample; SAMN02205338
BioSample; SAMN02743421
BioSample; SAMN02744161
Encyclopedic resources Wikidata; Q93450976
Entry history
Entry creation24-May-2019
Last entry update21-Mar-2023
Version number3