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Cellosaurus Lec23 (CVCL_VU64)

[Text version]

Cell line name Lec23
Synonyms CHO-Lec23; Pro-Lec23.11C
Accession CVCL_VU64
Resource Identification Initiative To cite this cell line use: Lec23 (RRID:CVCL_VU64)
Comments Selected for resistance to: UniProtKB; P02879; Ricinus communis ricin.
Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from sampling site: Ovary.
Sequence variations Mogs p.Ser330Phe (c.989C>T); but based on UniProtKB/TrEMBL G3I7V6 which is probably not full length (PubMed=15383536).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_4382 (CHO Pro-5)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=2360093; DOI=10.1007/BF01233357
Stanley P., Sallustio S., Krag S.S., Dunn B.
Lectin-resistant CHO cells: selection of seven new mutants resistant to ricin.
Somat. Cell Mol. Genet. 16:211-223(1990)

PubMed=1660460
Ray M.K., Yang J., Sundaram S., Stanley P.
A novel glycosylation phenotype expressed by Lec23, a Chinese hamster ovary mutant deficient in alpha-glucosidase I.
J. Biol. Chem. 266:22818-22825(1991)

PubMed=15383536; DOI=10.1074/jbc.M410121200
Hong Y., Sundaram S., Shin D.-J., Stanley P.
The Lec23 Chinese hamster ovary mutant is a sensitive host for detecting mutations in alpha-glucosidase I that give rise to congenital disorder of glycosylation IIb (CDG IIb).
J. Biol. Chem. 279:49894-49901(2004)

Cross-references
Other Wikidata; Q95982032
Entry history
Entry creation24-May-2019
Last entry updated02-Jul-2020
Version number3