ID   Lec23
SY   CHO-Lec23; Pro-Lec23.11C
DR   Wikidata; Q95982032
RX   PubMed=1660460;
RX   PubMed=2360093;
RX   PubMed=15383536;
CC   Selected for resistance to: UniProtKB; P02879; Ricinus communis ricin.
CC   Sequence variation: Mutation; UniProtKB; G3I7V6; Mogs; Simple; p.Ser330Phe (c.989C>T); Zygosity=Unspecified; Note=Position based on a sequence which is probably not full length (PubMed=15383536).
CC   Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Derived from sampling site: Ovary.
OX   NCBI_TaxID=10029; ! Cricetulus griseus
HI   CVCL_4382 ! CHO Pro-5
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 24-05-19; Last updated: 20-05-21; Version: 5
RX   PubMed=1660460; DOI=10.1016/S0021-9258(18)54427-6;
RA   Ray M.K., Yang J., Sundaram S., Stanley P.;
RT   "A novel glycosylation phenotype expressed by Lec23, a Chinese hamster
RT   ovary mutant deficient in alpha-glucosidase I.";
RL   J. Biol. Chem. 266:22818-22825(1991).
RX   PubMed=2360093; DOI=10.1007/BF01233357;
RA   Stanley P., Sallustio S., Krag S.S., Dunn B.;
RT   "Lectin-resistant CHO cells: selection of seven new mutants resistant
RT   to ricin.";
RL   Somat. Cell Mol. Genet. 16:211-223(1990).
RX   PubMed=15383536; DOI=10.1074/jbc.M410121200;
RA   Hong Y., Sundaram S., Shin D.-J., Stanley P.;
RT   "The Lec23 Chinese hamster ovary mutant is a sensitive host for
RT   detecting mutations in alpha-glucosidase I that give rise to
RT   congenital disorder of glycosylation IIb (CDG IIb).";
RL   J. Biol. Chem. 279:49894-49901(2004).