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Cellosaurus NB4-B1 (CVCL_VV78)

[Text version]

Cell line name NB4-B1
Accession CVCL_VV78
Resource Identification Initiative To cite this cell line use: NB4-B1 (RRID:CVCL_VV78)
Comments Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from sampling site: Bone marrow.
Sequence variations PML-RARA gene fusion (PubMed=12353268).
Heterozygous for KRAS p.Ala18Asp (c.53C>A) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line

PubMed=12353268; DOI=10.1002/gcc.10117
Mozziconacci M.-J., Rosenauer A., Restouin A., Fanelli M., Shao W., Fernandez F., Toiron Y., Viscardi J., Gambacorti-Passerini C., Miller W.H. Jr., Lafage-Pochitaloff M.
Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones.
Genes Chromosomes Cancer 35:261-270(2002)

Other Wikidata; Q95992298
Entry history
Entry creation24-May-2019
Last entry update02-Jul-2020
Version number4