ID   NB4-B1
AC   CVCL_VV78
DR   Wikidata; Q95992298
RX   PubMed=12353268;
CC   Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
CC   Sequence variation: PML-RARA gene fusion (PubMed=12353268).
CC   Sequence variation: Heterozygous for KRAS p.Ala18Asp (c.53C>A) (from parent cell line).
CC   Sequence variation: Homozygous for TP53 p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (from parent cell line).
CC   Derived from sampling site: Bone marrow.
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0005 ! NB4
SX   Female
AG   23Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 02-07-20; Version: 4
//
RX   PubMed=12353268; DOI=10.1002/gcc.10117;
RA   Mozziconacci M.-J., Rosenauer A., Restouin A., Fanelli M., Shao W.,
RA   Fernandez F., Toiron Y., Viscardi J., Gambacorti-Passerini C.,
RA   Miller W.H. Jr., Lafage-Pochitaloff M.;
RT   "Molecular cytogenetics of the acute promyelocytic leukemia-derived
RT   cell line NB4 and of four all-trans retinoic acid-resistant
RT   subclones.";
RL   Genes Chromosomes Cancer 35:261-270(2002).
//