ID   NB4-D5
AC   CVCL_VV79
SY   NB4D5
DR   cancercelllines; CVCL_VV79
DR   Wikidata; Q95992300
RX   PubMed=8839862;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (PubMed=8839862).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0005 ! NB4
SX   Female
AG   23Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 05-10-23; Version: 10
//
RX   PubMed=8839862; DOI=10.1182/blood.V88.7.2671.bloodjournal8872671;
RA   Rosenauer A., Raelson J.V., Nervi C., Eydoux P., DeBlasio A.,
RA   Miller W.H. Jr.;
RT   "Alterations in expression, binding to ligand and DNA, and
RT   transcriptional activity of rearranged and wild-type retinoid
RT   receptors in retinoid-resistant acute promyelocytic leukemia cell
RT   lines.";
RL   Blood 88:2671-2682(1996).
//