| Cell line name |
NB4-MR2 |
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| Synonyms |
NB4MR2; MR2 |
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| Accession |
CVCL_VV80 |
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| Resource Identification Initiative |
To cite this cell line use: NB4-MR2 (RRID:CVCL_VV80) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. |
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| Sequence variations |
- Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (PubMed=8839862; PubMed=9192750).
- Mutation; HGNC; 9864; RARA; Simple; p.Leu398Pro (c.1193T>C); Zygosity=Unspecified; Note=Equivalent to p.Leu890Pro in the PML-RARA fusion protein responsible for retinoic acid resistance (PubMed=9192750).
- Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
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| Disease |
Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_VV79 (NB4-D5) |
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| Sex of cell |
Female |
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| Age at sampling |
23Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8839862; DOI=10.1182/blood.V88.7.2671.bloodjournal8872671
Rosenauer A., Raelson J.V., Nervi C., Eydoux P., DeBlasio A., Miller W.H. Jr.
Alterations in expression, binding to ligand and DNA, and transcriptional activity of rearranged and wild-type retinoid receptors in retinoid-resistant acute promyelocytic leukemia cell lines.
Blood 88:2671-2682(1996) PubMed=9192750; DOI=10.1182/blood.V89.12.4282
Shao W.-L., Benedetti L., Lamph W.W., Nervi C., Miller W.H. Jr.
A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation.
Blood 89:4282-4289(1997) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_VV80
|
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| Encyclopedic resources |
Wikidata; Q95992314
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| Entry history |
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| Entry creation | 24-May-2019 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 10 |
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