ID   NB4-MR6
AC   CVCL_VV81
SY   NB4MR6; MR6
DR   Wikidata; Q95992316
RX   PubMed=8839862;
RX   PubMed=9192750;
CC   Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
CC   Sequence variation: Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (PubMed=9192750).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from sampling site: Bone marrow.
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_VV79 ! NB4-D5
SX   Female
AG   23Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 20-05-21; Version: 7
//
RX   PubMed=8839862; DOI=10.1182/blood.V88.7.2671.bloodjournal8872671;
RA   Rosenauer A., Raelson J.V., Nervi C., Eydoux P., DeBlasio A.,
RA   Miller W.H. Jr.;
RT   "Alterations in expression, binding to ligand and DNA, and
RT   transcriptional activity of rearranged and wild-type retinoid
RT   receptors in retinoid-resistant acute promyelocytic leukemia cell
RT   lines.";
RL   Blood 88:2671-2682(1996).
//
RX   PubMed=9192750; DOI=10.1182/blood.V89.12.4282;
RA   Shao W., Benedetti L., Lamph W.W., Nervi C., Miller W.H. Jr.;
RT   "A retinoid-resistant acute promyelocytic leukemia subclone expresses
RT   a dominant negative PML-RAR alpha mutation.";
RL   Blood 89:4282-4289(1997).
//