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Cellosaurus NB4-R4 (CVCL_VV82)

[Text version]

Cell line name NB4-R4
Synonyms NB4R4; R4
Accession CVCL_VV82
Resource Identification Initiative To cite this cell line use: NB4-R4 (RRID:CVCL_VV82)
Comments Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from sampling site: Bone marrow.
Sequence variations Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (PubMed=8839862; PubMed=9192750; PubMed=12353268).
Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 9864; RARA; Simple; p.Leu398Pro (c.1193T>C); Zygosity=Unspecified; Note=Equivalent to p.Leu890Pro in the PML-RARA fusion protein (PubMed=9192750).
Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VV79 (NB4-D5)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line

PubMed=8839862; DOI=10.1182/blood.V88.7.2671.bloodjournal8872671
Rosenauer A., Raelson J.V., Nervi C., Eydoux P., DeBlasio A., Miller W.H. Jr.
Alterations in expression, binding to ligand and DNA, and transcriptional activity of rearranged and wild-type retinoid receptors in retinoid-resistant acute promyelocytic leukemia cell lines.
Blood 88:2671-2682(1996)

PubMed=9192750; DOI=10.1182/blood.V89.12.4282
Shao W., Benedetti L., Lamph W.W., Nervi C., Miller W.H. Jr.
A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation.
Blood 89:4282-4289(1997)

PubMed=12353268; DOI=10.1002/gcc.10117
Mozziconacci M.-J., Rosenauer A., Restouin A., Fanelli M., Shao W.-L., Fernandez F., Toiron Y., Viscardi J., Gambacorti-Passerini C., Miller W.H. Jr., Lafage-Pochitaloff M.
Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones.
Genes Chromosomes Cancer 35:261-270(2002)

Other Wikidata; Q95992318
Entry history
Entry creation24-May-2019
Last entry update20-May-2021
Version number7