ID   KM12-L4A
AC   CVCL_W220
SY   Km 12 L4A; KM12L4-A; KM12L4A; KM12L4a
DR   cancercelllines; CVCL_W220
DR   Wikidata; Q54900058
RX   PubMed=3349467;
RX   PubMed=15170669;
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12496.
CC   Registration: Chiron Master Culture Collection; CMCC 11606 (CMCC #11606).
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 8031; NTRK1 + HGNC; 12012; TPM3; Name(s)=TPM3-NTRK1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Asn1819fs*7 (c.5454_5455insA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129Ter (c.385G>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val73Trpfs*50 (c.216delC) (p.P72fs); ClinVar=VCV000428897; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His179Arg (c.536A>G); ClinVar=VCV000376606; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5946 ! KM12-L4
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 05-10-23; Version: 17
//
RX   PubMed=3349467;
RA   Morikawa K., Walker S.M., Jessup J.M., Fidler I.J.;
RT   "In vivo selection of highly metastatic cells from surgical specimens
RT   of different primary human colon carcinomas implanted into nude
RT   mice.";
RL   Cancer Res. 48:1943-1948(1988).
//
RX   PubMed=15170669; DOI=10.1002/ijc.20195;
RA   Camps J., Morales C., Prat E., Ribas M., Capella G., Egozcue J.,
RA   Peinado M.A., Miro R.;
RT   "Genetic evolution in colon cancer KM12 cells and metastatic
RT   derivates.";
RL   Int. J. Cancer 110:869-874(2004).
//