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Cellosaurus KY-MTX (CVCL_W293)

[Text version]

Cell line name KY-MTX
Synonyms KY821/MTX
Accession CVCL_W293
Resource Identification Initiative To cite this cell line use: KY-MTX (RRID:CVCL_W293)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from sampling site: Brain; meninges.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Acute myelomonocytic leukemia (NCIt: C7463)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1346 (KY821)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Publications

PubMed=1560671; DOI=10.1016/0145-2126(92)90059-G
Saito H., Kishi K., Narita M., Furukawa T., Nagura E., Maekawa T., Abe T., Shibata A.
A new myeloblastic leukemia cell line with double minute chromosomes Induction of methotrexate resistance and dihydrofolate reductase gene amplification.
Leuk. Res. 16:217-226(1992)

PubMed=8387619; DOI=10.1016/0145-2126(93)90019-H
Fukuda T., Kakihara T., Kamishima T., Ohnishi Y., Naito M., Kishi K., Shibata A.
Different effects of various hematopoietic growth factors on myelomonocytic cell line (KY-821) and its drug-resistant sublines.
Leuk. Res. 17:325-332(1993)

Cross-references
Other Wikidata; Q54900770
Entry history
Entry creation16-Apr-2014
Last entry update20-May-2021
Version number10