ID   KY-MTX
AC   CVCL_W293
SY   KY821/MTX
DR   cancercelllines; CVCL_W293
DR   Wikidata; Q54900770
RX   PubMed=1560671;
RX   PubMed=8387619;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Brain, meninges; UBERON=UBERON_0010743.
DI   NCIt; C7463; Acute myelomonocytic leukemia
DI   ORDO; Orphanet_517; Acute myelomonocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1346 ! KY821
SX   Male
AG   28Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 05-10-23; Version: 13
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RX   PubMed=1560671; DOI=10.1016/0145-2126(92)90059-G;
RA   Saito H., Kishi K., Narita M., Furukawa T., Nagura E.-i., Maekawa T.,
RA   Abe T., Shibata A.;
RT   "A new myeloblastic leukemia cell line with double minute chromosomes.
RT   Induction of methotrexate resistance and dihydrofolate reductase gene
RT   amplification.";
RL   Leuk. Res. 16:217-226(1992).
//
RX   PubMed=8387619; DOI=10.1016/0145-2126(93)90019-H;
RA   Fukuda T., Kakihara T., Kamishima T., Ohnishi Y., Naito M., Kishi K.,
RA   Shibata A.;
RT   "Different effects of various hematopoietic growth factors on
RT   myelomonocytic cell line (KY-821) and its drug-resistant sublines.";
RL   Leuk. Res. 17:325-332(1993).
//