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Cellosaurus KY-Ra (CVCL_W294)

[Text version]
Cell line name KY-Ra
Accession CVCL_W294
Resource Identification Initiative To cite this cell line use: KY-Ra (RRID:CVCL_W294)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:28680; Cytarabine (Arabinosylcytosine; Ara-C).
Derived from site: In situ; Brain, meninges; UBERON=UBERON_0010743.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Acute myelomonocytic leukemia (NCIt: C7463)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1346 (KY821)
Children:
CVCL_Z939 (KY-ADR1)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Publications

CLPUB00209
Kakihara T.
The characterization of highly resistant human leukemic cell lines to 1-beta-D-arabinofuranosylcytosine.
Acta Med. Biol. 39:119-127(1991)

PubMed=8387619; DOI=10.1016/0145-2126(93)90019-H
Fukuda T., Kakihara T., Kamishima T., Ohnishi Y., Naito M., Kishi K., Shibata A.
Different effects of various hematopoietic growth factors on myelomonocytic cell line (KY-821) and its drug-resistant sublines.
Leuk. Res. 17:325-332(1993)

PubMed=12716468; DOI=10.1111/j.1349-7006.2002.tb01336.x
Shimizu H., Fukuda T., Ghazizadeh M., Nagashima M., Kawanami O., Suzuki T.
Molecular cytogenetic characterization of drug-resistant leukemia cell lines by comparative genomic hybridization and fluorescence in situ hybridization.
Jpn. J. Cancer Res. 93:902-910(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_W294
Encyclopedic resources Wikidata; Q54900771
Entry history
Entry creation16-Apr-2014
Last entry update05-Oct-2023
Version number15