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Cellosaurus KY-VCR (CVCL_W295)

[Text version]

Cell line name KY-VCR
Accession CVCL_W295
Resource Identification Initiative To cite this cell line use: KY-VCR (RRID:CVCL_W295)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
Derived from sampling site: Brain; meninges.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Acute myelomonocytic leukemia (NCIt: C7463)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1346 (KY821)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line

PubMed=1472928; DOI=10.3109/10428199209053617
Kakihara T., Yamada T., Fukuda T., Ohnishi Y., Kishi K., Shibata A.
Vincristine-resistant human leukemia cell line: new monoclonal antibodies to a 65kDa membrane protein.
Leuk. Lymphoma 7:157-164(1992)

PubMed=8387619; DOI=10.1016/0145-2126(93)90019-H
Fukuda T., Kakihara T., Kamishima T., Ohnishi Y., Naito M., Kishi K., Shibata A.
Different effects of various hematopoietic growth factors on myelomonocytic cell line (KY-821) and its drug-resistant sublines.
Leuk. Res. 17:325-332(1993)

PubMed=12716468; DOI=10.1111/j.1349-7006.2002.tb01336.x
Shimizu H., Fukuda T., Ghazizadeh M., Nagashima M., Kawanami O., Suzuki T.
Molecular cytogenetic characterization of drug-resistant leukemia cell lines by comparative genomic hybridization and fluorescence in situ hybridization.
Jpn. J. Cancer Res. 93:902-910(2002)

Other Wikidata; Q54900773
Entry history
Entry creation16-Apr-2014
Last entry update20-May-2021
Version number11