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Cellosaurus Ishikawa 3-H-4 (CVCL_W435)

[Text version]
Cell line name Ishikawa 3-H-4
Accession CVCL_W435
Resource Identification Initiative To cite this cell line use: Ishikawa 3-H-4 (RRID:CVCL_W435)
Comments Population: Japanese.
Doubling time: 31.6 hours (PubMed=9183638).
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2529 (Ishikawa)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): PubMed=22710073

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,20
D3S135816,17
D5S81810,11
D7S8209,10
D8S117912,16
D13S3179,12
D16S5399
D18S5113,21,22
D19S43312.2,14
D21S1128
FGA21,22
TH019,10
TPOX8
vWA14,17

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Publications

PubMed=9183638
Nishida M., Kasahara K., Oki A., Satoh T., Arai Y., Kubo T.
Establishment of eighteen clones of Ishikawa cells.
Hum. Cell 9:109-116(1996)

DOI=10.1007/978-4-431-53981-0_2
Nishida M.
Ishikawa cells: opening of in vitro hormone research on endometrial carcinoma.
(In) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.35-58; Springer; Tokyo (2003)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_W435
Encyclopedic resources Wikidata; Q54898300
Entry history
Entry creation16-Apr-2014
Last entry update05-Oct-2023
Version number13