Cellosaurus cell line W-ES (CVCL_W528)

• Gene fusion; HGNC; 3446; ERG + HGNC; 3508; EWSR1; Name(s)=EWSR1-ERG, EWS-ERG (PubMed=9738976).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Unspecified (PubMed=8221663).
  

PubMed=2486606
Fujii Y., Nakagawa Y., Hongo T., Igarashi Y., Naito Y., Maeda M.
Cell line of small round cell tumor originating in the chest wall: W-ES.
Hum. Cell 2:190-191(1989)

PubMed=2731119; DOI=10.1002/1097-0142(19890701)64:1<43::AID-CNCR2820640109>3.0.CO;2-F
Fujii Y., Hongo T., Nakagawa Y., Nasuda K., Mizuno Y., Igarashi Y., Naito Y., Maeda M.
Cell culture of small round cell tumor originating in the thoracopulmonary region. Evidence for derivation from a primitive pluripotent cell.
Cancer 64:43-51(1989)

PubMed=8221663
Komuro H., Hayashi Y., Kawamura M., Hayashi K., Kaneko Y., Kamoshita S., Hanada R., Yamamoto K., Hongo T., Yamada M., Tsuchida Y.
Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas.
Cancer Res. 53:5284-5288(1993)

PubMed=9738976; DOI=10.1111/j.1349-7006.1998.tb03274.x
Urano F., Umezawa A., Yabe H., Hong W., Yoshida K., Fujinaga K., Hata J.-i.
Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF, available for diagnosis.
Jpn. J. Cancer Res. 89:703-711(1998)

PubMed=12054564; DOI=10.1016/S0006-291X(02)00129-8
Yabe H., Fukuma M., Urano F., Yoshida K., Kato S., Toyama Y., Hata J.-i., Umezawa A.
Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo.
Biochem. Biophys. Res. Commun. 293:61-71(2002)