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Cellosaurus L2-2Mut (CVCL_W603)

[Text version]

Cell line name L2-2Mut
Synonyms IM2; MPIi003-A
Accession CVCL_W603
Resource Identification Initiative To cite this cell line use: L2-2Mut (RRID:CVCL_W603)
Comments From: Max Planck Institute for Molecular Biomedicine; Munster; Germany.
Sequence variations Heterozygous for LRRK2 p.Gly2019Ser (c.6055G>A) (PubMed=23472874).
Disease Parkinson's disease (NCIt: C26845)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_W602 (L2-2GC)
Originate from same individual CVCL_W601 ! L2-1Mut
CVCL_W605 ! L2-3Mut
Sex of cell Female
Age at sampling 80-82Y
Category Induced pluripotent stem cell
Publications

PubMed=23472874; DOI=10.1016/j.stem.2013.01.008
Reinhardt P., Schmid B., Burbulla L.F., Schondorf D.C., Wagner L., Glatza M., Hoing S., Hargus G., Heck S.A., Dhingra A., Wu G., Muller S., Brockmann K., Kluba T., Maisel M., Kruger R., Berg D., Tsytsyura Y., Thiel C.S., Psathaki O.E., Klingauf J., Kuhlmann T., Klewin M., Muller H., Gasser T., Scholer H.R., Sterneckert J.
Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.
Cell Stem Cell 12:354-367(2013)

Cross-references
Cell line databases/resources hPSCreg; MPIi003-A
SKIP; SKIP000298
Biological sample resources BioSamples; SAMEA104382072
Other Wikidata; Q54900990
Entry history
Entry creation16-Apr-2014
Last entry updated25-Feb-2019
Version number5