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Cellosaurus G-mel (CVCL_W798)

[Text version]

Cell line name G-mel
Synonyms G-MEL
Accession CVCL_W798
Resource Identification Initiative To cite this cell line use: G-mel (RRID:CVCL_W798)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.75
Native American0.58
East Asian, North2.61
East Asian, South0.16
South Asian0
European, North66.24
European, South29.66
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811
D7S8208,11
D13S31710,11
D16S5399,13
TH017,9.3
TPOX8,9
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=10766161
Tsao H., Zhang X., Fowlkes K., Haluska F.G.
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.
Cancer Res. 60:1800-1804(2000)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; GMEL_SKIN
Cell_Model_Passport; SIDM00129
Cosmic-CLP; 1240130
DepMap; ACH-002121
Chemistry resources GDSC; 1240130
PharmacoDB; GMEL_376_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669811
Other Wikidata; Q54835354
Polymorphism and mutation databases Cosmic; 706101
Entry history
Entry creation17-Jul-2014
Last entry update20-May-2021
Version number15