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Cellosaurus HD10.6 (CVCL_WG82)

[Text version]

Cell line name HD10.6
Accession CVCL_WG82
Resource Identification Initiative To cite this cell line use: HD10.6 (RRID:CVCL_WG82)
Comments Characteristics: Immortalized dorsal root ganglion (DRG) cell line that in the presence of doxycycline can differentiate into sensory neurons with nociceptive features (PubMed=10377351).
Characteristics: Susceptible to infection by herpes simplex virus 1 (HSV-1). A quiescent state resembling latency can be established in the HSV-1 infection in the presence of acyclovir (PubMed=28404842).
Doubling time: 1.2 days (PubMed=10377351).
Transfected with: UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: v-Myc; tetracycline-regulated.
Miscellaneous: STR profile from personal communication of Triezenberg S.J.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling <12FW
Category Transformed cell line
STR profile Source(s): Direct_author_submission


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PubMed=10377351; DOI=10.1523/JNEUROSCI.19-13-05420.1999
Raymon H.K., Thode S., Zhou J., Friedman G.C., Pardinas J.R., Barrere C., Johnson R.M., Sah D.W.Y.
Immortalized human dorsal root ganglion cells differentiate into neurons with nociceptive properties.
J. Neurosci. 19:5420-5428(1999)

Thellman N.M.
A human neuronal model for herpes simplex virus latency and reactivation.
Thesis PhD (2017), Van Andel Research Institute, United States

PubMed=28404842; DOI=10.1128/JVI.00080-17
Thellman N.M., Botting C., Madaj Z., Triezenberg S.J.
An immortalized human dorsal root ganglion cell line provides a novel context to study herpes simplex virus 1 latency and reactivation.
J. Virol. 91:e00080.17-e00080.17(2017)

Entry history
Entry creation24-May-2019
Last entry updated24-May-2019
Version number1