ID   HD10.6
AC   CVCL_WG82
DR   Wikidata; Q93986083
RX   CelloPub=CLPUB00486;
RX   PubMed=10377351;
RX   PubMed=28404842;
RX   PubMed=32636736;
RX   PubMed=35890047;
CC   Characteristics: Immortalized dorsal root ganglion (DRG) cell line that in the presence of doxycycline can differentiate into sensory neurons with nociceptive features (PubMed=10377351).
CC   Virology: Susceptible to infection by herpes simplex virus 1 (HHV-1). A quiescent state resembling latency can be established in the HSV-1 infection in the presence of acyclovir (PubMed=28404842).
CC   Doubling time: 1.2 days (PubMed=10377351).
CC   Transfected with: UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: v-Myc [Note=Tetracycline-regulated].
CC   Miscellaneous: STR profile from personal communication of Triezenberg S.J.
CC   Derived from site: In situ; Dorsal root ganglion; UBERON=UBERON_0000044.
CC   Cell type: Neuron; CL=CL_0000540.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 9,10
ST   D5S818: 11,12
ST   D7S820: 10,13
ST   TH01: 8,9.3
ST   TPOX: 10,12
ST   vWA: 15,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   <12FW
CA   Transformed cell line
DT   Created: 24-05-19; Last updated: 05-10-23; Version: 8
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RX   CelloPub=CLPUB00486;
RA   Thellman N.M.;
RT   "A human neuronal model for herpes simplex virus latency and
RT   reactivation.";
RL   Thesis PhD (2017), Van Andel Research Institute, United States.
//
RX   PubMed=10377351; DOI=10.1523/JNEUROSCI.19-13-05420.1999;
RA   Raymon H.K., Thode S., Zhou J.-Y., Friedman G.C., Pardinas J.R.,
RA   Barrere C., Johnson R.M., Sah D.W.Y.;
RT   "Immortalized human dorsal root ganglion cells differentiate into
RT   neurons with nociceptive properties.";
RL   J. Neurosci. 19:5420-5428(1999).
//
RX   PubMed=28404842; DOI=10.1128/JVI.00080-17;
RA   Thellman N.M., Botting C., Madaj Z., Triezenberg S.J.;
RT   "An immortalized human dorsal root ganglion cell line provides a novel
RT   context to study herpes simplex virus 1 latency and reactivation.";
RL   J. Virol. 91:e00080.17.1-e00080.17.18(2017).
//
RX   PubMed=32636736; DOI=10.3389/fncel.2020.00184;
RA   Haberberger R.V., Barry C.M., Matusica D.;
RT   "Immortalized dorsal root ganglion neuron cell lines.";
RL   Front. Cell. Neurosci. 14:184.1-184.21(2020).
//
RX   PubMed=35890047; DOI=10.3390/pathogens11070803;
RA   Chen Y.-C., Li H.-D., Martin-Caraballo M., Hsia S.-C.V.;
RT   "Establishing a herpesvirus quiescent infection in differentiated
RT   human dorsal root ganglion neuronal cell line mediated by micro-RNA
RT   overexpression.";
RL   Pathogens 11:803.1-803.12(2022).
//