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Cellosaurus MELN (CVCL_WI91)

[Text version]
Cell line name MELN
Synonyms MCF-7 ERE-beta-globin Luciferase Neo
Accession CVCL_WI91
Resource Identification Initiative To cite this cell line use: MELN (RRID:CVCL_WI91)
Comments Population: Caucasian.
Biotechnology: Used in a bioluminescent bioassay to quantitatively measure estrogenic compounds.
Characteristics: The luciferase reporter gene is under the control of an estrogen-responsive element from the beta-globin promoter.
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=10492897; DOI=10.1016/S0048-9697(99)00178-3
Balaguer P., Francois F., Comunale F., Fenet H., Boussioux A.-M., Pons M., Nicolas J.-C., Casellas C.
Reporter cell lines to study the estrogenic effects of xenoestrogens.
Sci. Total Environ. 233:47-56(1999)

PubMed=11312541; DOI=10.1002/bio.630
Balaguer P., Boussioux A.-M., Demirpence E., Nicolas J.-C.
Reporter cell lines are useful tools for monitoring biological activity of nuclear receptor ligands.
Luminescence 16:153-158(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WI91
Encyclopedic resources Wikidata; Q95988749
Entry history
Entry creation24-May-2019
Last entry update05-Oct-2023
Version number9