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Cellosaurus MCF-7 R27 (CVCL_WK73)

[Text version]

Cell line name MCF-7 R27
Synonyms R27
Accession CVCL_WK73
Resource Identification Initiative To cite this cell line use: MCF-7 R27 (RRID:CVCL_WK73)
Comments Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
HLA typing Source: PubMed=9023415
Class I
HLA-AA*02:01
HLA-BB*44:02
HLA-CC*05:01
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7228867
Nawata H., Bronzert D., Lippman M.E.
Isolation and characterization of a tamoxifen-resistant cell line derived from MCF-7 human breast cancer cells.
J. Biol. Chem. 256:5016-5021(1981)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

Cross-references
Other Wikidata; Q95986105
Entry history
Entry creation24-May-2019
Last entry update02-Jul-2020
Version number2