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Cellosaurus MG63.3 (CVCL_WL01)

[Text version]
Cell line name MG63.3
Accession CVCL_WL01
Resource Identification Initiative To cite this cell line use: MG63.3 (RRID:CVCL_WL01)
Comments Population: Caucasian.
Characteristics: Has a high metastatic potential.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Bone, left femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_R705 (MG63.2)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=26320182; DOI=10.18632/oncotarget.5177
Ren L., Mendoza A., Zhu J., Briggs J.W., Halsey C., Hong E.S., Burkett S.S., Morrow J.J., Lizardo M.M., Osborne T., Li S.Q., Luu H.H., Meltzer P.S., Khanna C.
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Oncotarget 6:29469-29481(2015)

PubMed=29334376; DOI=10.1038/nm.4475
Morrow J.J., Bayles I., Funnell A.P.W., Miller T.E., Saiakhova A., Lizardo M.M., Bartels C.F., Kapteijn M.Y., Hung S., Mendoza A., Dhillon G., Chee D.R., Myers J.T., Allen F., Gambarotti M., Righi A., DiFeo A., Rubin B.P., Huang A.Y., Meltzer P.S., Helman L.J., Picci P., Versteeg H., Stamatoyannopoulos J.A., Khanna C., Scacheri P.C.
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
Nat. Med. 24:176-185(2018)

Cross-references
Encyclopedic resources Wikidata; Q95989262
Gene expression databases GEO; GSM1915000
GEO; GSM1915001
GEO; GSM1915002
GEO; GSM1915003
GEO; GSM1915030
GEO; GSM1915031
GEO; GSM1915032
GEO; GSM2635313
GEO; GSM2635314
Entry history
Entry creation24-May-2019
Last entry update29-Jun-2023
Version number8