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Cellosaurus HTC75 (CVCL_WM79)

[Text version]

Cell line name HTC75
Accession CVCL_WM79
Resource Identification Initiative To cite this cell line use: HTC75 (RRID:CVCL_WM79)
Comments Characteristics: Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16.
Transfected with: UniProtKB; P04483; E.coli Tn10 tetR.
Transfected with: UniProtKB; P00557; E.coli hygromycin-B 4-O-kinase (hph).
Transfected with: UniProtKB; P04486; Human herpesvirus 1 VP16 (UL28) (with del 1-360).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for IDH1 p.Arg132Cys (c.394C>T) (from parent cell line).
Heterozygous for NRAS p.Gln61Lys (c.181C>A) (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Children:
CVCL_WM80 (HTC75 T19)CVCL_WM81 (HTC75 T4)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=9034193; DOI=10.1038/385740a0
van Steensel B., de Lange T.
Control of telomere length by the human telomeric protein TRF1.
Nature 385:740-743(1997)

PubMed=9476899; DOI=10.1016/S0092-8674(00)80932-0
van Steensel B., Smogorzewska A., de Lange T.
TRF2 protects human telomeres from end-to-end fusions.
Cell 92:401-413(1998)

Entry history
Entry creation24-May-2019
Last entry updated24-May-2019
Version number1