ID   HTC75 T4
AC   CVCL_WM81
SY   HTC75T4; HTC75 clone T4; T4
DR   cancercelllines; CVCL_WM81
DR   Wikidata; Q94305591
RX   PubMed=9476899;
CC   Population: Caucasian.
CC   Characteristics: Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 11729; TERF2 (with p.Met1_Ala44del and p.Lys501_Asn542 and a N-terminal FLAG tag = TRF2deltaBdeltaM).
CC   Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with p.Met1_Arg360del).
CC   Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
DI   NCIt; C3043; Fibrosarcoma
DI   ORDO; Orphanet_2030; Fibrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_WM79 ! HTC75
SX   Male
AG   35Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 05-10-23; Version: 13
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RX   PubMed=9476899; DOI=10.1016/S0092-8674(00)80932-0;
RA   van Steensel B., Smogorzewska A., de Lange T.;
RT   "TRF2 protects human telomeres from end-to-end fusions.";
RL   Cell 92:401-413(1998).
//