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Cellosaurus Jurkat E6.1 NF-kappaB::eGFP (CVCL_WN96)

[Text version]

Cell line name Jurkat E6.1 NF-kappaB::eGFP
Accession CVCL_WN96
Resource Identification Initiative To cite this cell line use: Jurkat E6.1 NF-kappaB::eGFP (RRID:CVCL_WN96)
Comments Characteristics: The eGFP reporter gene is under control of a NF-kappaB promoter element.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (from parent cell line).
Heterozygous for BAX p.Glu41Glyfs*33 (c.121dupG) (ClinVar=VCV000009511) (from parent cell line).
Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (from parent cell line).
Heterozygous for INPP5D p.Gln345Ter (c.1033C>T) (from parent cell line).
Heterozygous for INPP5D c.1097+1065_1097+1112del47 (from parent cell line).
Homozygous for MSH2 p.Arg711Ter (c.2131C>T) (ClinVar=VCV000090903) (from parent cell line).
Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (ClinVar=VCV000089363) (from parent cell line).
Heterozygous for SYK p.Met34Hisfs*3 (c.98_99insG) (from parent cell line).
Heterozygous for TP53 p.Arg196Ter (c.586C>T) (ClinVar=VCV000043589) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Children:
CVCL_WN97 (JE6-1REP-iNKT)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=25500904; DOI=10.1038/srep07438
Ratzinger F., Haslacher H., Poeppl W., Hoermann G., Kovarik J.J., Jutz S., Steinberger P., Burgmann H., Pickl W.F., Schmetterer K.G.
Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity.
Sci. Rep. 4:7438-7438(2014)

PubMed=29029399; DOI=10.18632/oncotarget.17615
Jutz S., Hennig A., Paster W., Asrak O., Dijanovic D., Kellner F., Pickl W.F., Huppa J.B., Leitner J., Steinberger P.
A cellular platform for the evaluation of immune checkpoint molecules.
Oncotarget 8:64892-64906(2017)

PubMed=31092850; DOI=10.1038/s41598-019-43529-4
Humeniuk P., Geiselhart S., Battin C., Webb T., Steinberger P., Paster W., Hoffmann-Sommergrsuber K.
Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor.
Sci. Rep. 9:7426-7426(2019)

Cross-references
Other Wikidata; Q94332818
Entry history
Entry creation05-Jul-2019
Last entry update12-Jan-2021
Version number5