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Cellosaurus UACC62R (CVCL_WU69)

[Text version]

Cell line name UACC62R
Accession CVCL_WU69
Resource Identification Initiative To cite this cell line use: UACC62R (RRID:CVCL_WU69)
Comments Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
Omics: Deep RNAseq analysis.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Pro248Thrfs*5 (c.741dupA) (c.741_742insA); ClinVar=VCV000142259; Zygosity=Homozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1780 (UACC-62)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line

Misek S.A., Appleton K.M., Dexheimer T., Lisabeth E.M., Lo R.S., Larsen S.D., Gallo K.A., Neubig R.R.
Rho-mediated MRTF and YAP1 activation contributes to BRAF inhibitor resistance in Sox9High/Sox10Low melanoma cells.
bioRxiv 2018:381806-381806(2018)

Encyclopedic resources Wikidata; Q98133801
Gene expression databases GEO; GSM3195613
GEO; GSM3195614
Entry history
Entry creation05-Jul-2019
Last entry update20-May-2021
Version number4