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Cellosaurus UACC62R (CVCL_WU69)

[Text version]

Cell line name UACC62R
Accession CVCL_WU69
Resource Identification Initiative To cite this cell line use: UACC62R (RRID:CVCL_WU69)
Comments Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
Omics: Deep RNAseq analysis.
Sequence variations Homozygous for BRAF p.Val600Glu (c.1799T>A) (ClinVar=VCV000013961) (from parent cell line).
Homozygous for PTEN p.Pro248Thrfs*5 (c.741dupA) (c.741_742insA) (ClinVar=VCV000142259) (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1780 (UACC-62)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

DOI=10.1101/381806
Misek S.A., Appleton K.M., Dexheimer T., Lisabeth E.M., Lo R.S., Larsen S.D., Gallo K.A., Neubig R.R.
Rho-mediated MRTF and YAP1 activation contributes to BRAF inhibitor resistance in Sox9High/Sox10Low melanoma cells.
bioRxiv 2018:381806-381806(2018)

Cross-references
Gene expression databases GEO; GSM3195613
GEO; GSM3195614
Other Wikidata; Q98133801
Entry history
Entry creation05-Jul-2019
Last entry update29-Oct-2020
Version number3