Due to scheduled maintenance work, this service will not be available from Tuesday August 23rd 06:00 pm until Wednesday August 24th 08:00 am
CEST. Apologies for the inconvenience.
Cellosaurus UACC62R (CVCL_WU69)
[Text version]
| Cell line name |
UACC62R
|
|---|
| Accession |
CVCL_WU69
|
|---|
| Resource Identification Initiative |
To cite this cell line use: UACC62R (RRID:CVCL_WU69) |
|---|
| Comments |
Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
Omics: Deep RNAseq analysis.
|
|---|
| Sequence variations |
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Pro248Thrfs*5 (c.741dupA) (c.741_742insA); ClinVar=VCV000142259; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Melanoma (NCIt: C3224)
|
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606)
|
|---|
| Hierarchy |
Parent: CVCL_1780 (UACC-62)
|
|---|
| Sex of cell |
Sex unspecified
|
|---|
| Age at sampling |
Age unspecified
|
|---|
| Category |
Cancer cell line
|
|---|
| Publications | DOI=10.1101/381806
Misek S.A., Appleton K.M., Dexheimer T., Lisabeth E.M., Lo R.S., Larsen S.D., Gallo K.A., Neubig R.R.
Rho-mediated MRTF and YAP1 activation contributes to BRAF inhibitor resistance in Sox9High/Sox10Low melanoma cells.
bioRxiv 2018:381806-381806(2018) |
|---|
| Cross-references |
|---|
| Encyclopedic resources |
Wikidata; Q98133801
|
|---|
| Gene expression databases |
GEO; GSM3195613
GEO; GSM3195614
|
|---|
| Entry history |
|---|
| Entry creation | 05-Jul-2019 |
|---|
| Last entry update | 20-May-2021 |
|---|
| Version number | 4 |
|---|