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Cellosaurus SupT1-R5 (CVCL_WU89)

[Text version]

Cell line name SupT1-R5
Synonyms SupT1-CCR5
Accession CVCL_WU89
Resource Identification Initiative To cite this cell line use: SupT1-R5 (RRID:CVCL_WU89)
Comments Transfected with: HGNC; 1606; CCR5.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Caution: There seems to be at least 3 different cell lines derived from Sup-T1 by transfection of human CCR5: Sup-T1-CCR5 (CVCL_X633), SupT1.CCR5 (CVCL_WU88) and SupT1-R5 (CVCL_WU89).
Derived from sampling site: Pleural effusion.
Sequence variations Mutation; HGNC; 3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T lymphoblastic lymphoma (NCIt: C7210)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1714 (SUP-T1)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
Publications

PubMed=24162716; DOI=10.1182/blood-2013-08-521229
Didigu C.A., Wilen C.B., Wang J., Duong J., Secreto A.J., Danet-Desnoyers G.A., Riley J.L., Gregory P.D., June C.H., Holmes M.C., Doms R.W.
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.
Blood 123:61-69(2014)

PubMed=25253335; DOI=10.1128/JVI.01543-14
Herold N., Anders-Osswein M., Glass B., Eckhardt M., Muller B., Krausslich H.-G.
HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at the plasma membrane and does not require endocytosis.
J. Virol. 88:13956-13970(2014)

PubMed=28233807; DOI=10.1038/srep43231
Fun A., Mok H.P., Wills M.R., Lever A.M.
A highly reproducible quantitative viral outgrowth assay for the measurement of the replication-competent latent HIV-1 reservoir.
Sci. Rep. 7:43231-43231(2017)

Cross-references
Other Wikidata; Q98132878
Entry history
Entry creation05-Jul-2019
Last entry update20-May-2021
Version number4