ID   SupT1-R5
AC   CVCL_WU89
SY   SupT1-CCR5
RX   PubMed=24162716;
RX   PubMed=25253335;
RX   PubMed=28233807;
CC   Sequence variation: Heterozygous for EGFR p.Cys251Tyr (c.752G>A) (from parent cell line).
CC   Sequence variation: Heterozygous for KIT p.Arg177His (c.530G>A) (from parent cell line).
CC   Sequence variation: Heterozygous for MET p.Arg191Trp (c.571C>T) (from parent cell line).
CC   Sequence variation: Heterozygous for PIK3CA p.Glu545Asp (c.1635G>T) and p.Glu970Lys (c.2908G>A) (from parent cell line).
CC   Sequence variation: Heterozygous for PTCH1 p.Arg682Cys (c.2044C>T) (from parent cell line).
CC   Sequence variation: Heterozygous for SPRY4 p.Arg48Trp (c.142C>T) (from parent cell line).
CC   Sequence variation: Heterozygous for TP53 p.Arg267Leu (c.800G>T) (from parent cell line).
CC   Transfected with: HGNC; 1606; CCR5.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Caution: There seems to be at least 3 different cell lines derived from Sup-T1 by transfection of human CCR5: Sup-T1-CCR5 (CVCL_X633), SupT1.CCR5 (CVCL_WU88) and SupT1-R5 (CVCL_WU89).
CC   Derived from sampling site: Pleural effusion.
DI   NCIt; C7210; Childhood T lymphoblastic lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_1714 ! SUP-T1
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 05-07-19; Version: 1
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RX   PubMed=24162716; DOI=10.1182/blood-2013-08-521229;
RA   Didigu C.A., Wilen C.B., Wang J., Duong J., Secreto A.J.,
RA   Danet-Desnoyers G.A., Riley J.L., Gregory P.D., June C.H.,
RA   Holmes M.C., Doms R.W.;
RT   "Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5
RT   and cxcr4 protects CD4+ T cells from HIV-1 infection.";
RL   Blood 123:61-69(2014).
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RX   PubMed=25253335; DOI=10.1128/JVI.01543-14;
RA   Herold N., Anders-Osswein M., Glass B., Eckhardt M., Muller B.,
RA   Krausslich H.-G.;
RT   "HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at
RT   the plasma membrane and does not require endocytosis.";
RL   J. Virol. 88:13956-13970(2014).
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RX   PubMed=28233807; DOI=10.1038/srep43231;
RA   Fun A., Mok H.P., Wills M.R., Lever A.M.;
RT   "A highly reproducible quantitative viral outgrowth assay for the
RT   measurement of the replication-competent latent HIV-1 reservoir.";
RL   Sci. Rep. 7:43231-43231(2017).
//