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Cellosaurus U-937/CR (CVCL_WV55)

[Text version]

Cell line name U-937/CR
Synonyms U937/CR
Accession CVCL_WV55
Resource Identification Initiative To cite this cell line use: U-937/CR (RRID:CVCL_WV55)
Comments Selected for resistance to: ChEBI; CHEBI:90225; Rubitecan (Orathecin; 9-nitrocamptothecin; 9NC).
Derived from sampling site: Pleural effusion.
Sequence variations PICALM-MLLT10 (CALM-AF10) gene fusion (from parent cell line).
Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (from parent cell line).
TOP1 p.Phe361Ser (c.1082T>C) (PubMed=8300570).
Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59); splice donor mutation (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=8300570
Rubin E., Pantazis P., Bharti A., Toppmeyer D., Giovanella B., Kufe D.
Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin.
J. Biol. Chem. 269:2433-2439(1994)

Entry history
Entry creation05-Jul-2019
Last entry update02-Jul-2020
Version number2