ID   U-937/CR
AC   CVCL_WV55
SY   U937/CR
DR   cancercelllines; CVCL_WV55
DR   Wikidata; Q98133713
RX   PubMed=8300570;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:90225; Rubitecan (Orathecin; 9-nitrocamptothecin; 9NC).
CC   Sequence variation: Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11986; TOP1; Simple; p.Phe361Ser (c.1082T>C); Zygosity=Unspecified (PubMed=8300570).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 05-10-23; Version: 9
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RX   PubMed=8300570; DOI=10.1016/S0021-9258(17)41964-8;
RA   Rubin E.H., Pantazis P., Bharti A., Toppmeyer D., Giovanella B.C.,
RA   Kufe D.W.;
RT   "Identification of a mutant human topoisomerase I with intact
RT   catalytic activity and resistance to 9-nitro-camptothecin.";
RL   J. Biol. Chem. 269:2433-2439(1994).
//