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Cellosaurus U-937 RERC (CVCL_WV56)

[Text version]

Cell line name U-937 RERC
Synonyms U937/RERC; RERC
Accession CVCL_WV56
Resource Identification Initiative To cite this cell line use: U-937 RERC (RRID:CVCL_WV56)
Comments Doubling time: ~22 hours (PubMed=9371509).
Selected for resistance to: ChEBI; CHEBI:90225; Rubitecan (Orathecin; 9-nitrocamptothecin; 9NC).
Derived from sampling site: Pleural effusion.
Sequence variations PICALM-MLLT10 (CALM-AF10) gene fusion (from parent cell line).
Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (from parent cell line).
TOP1 p.Asp533Asn (c.1597G>A) (PubMed=9371509).
Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59); splice donor mutation (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=9371509
Saleem A., Ibrahim N., Patel M., Li X.G., Gupta E., Mendoza J., Pantazis P., Rubin E.H.
Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning.
Cancer Res. 57:5100-5106(1997)

Entry history
Entry creation05-Jul-2019
Last entry update02-Jul-2020
Version number2