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Cellosaurus U-937 RERC (CVCL_WV56)

[Text version]

Cell line name U-937 RERC
Synonyms U937/RERC; RERC
Accession CVCL_WV56
Resource Identification Initiative To cite this cell line use: U-937 RERC (RRID:CVCL_WV56)
Comments Doubling time: ~22 hours (PubMed=9371509).
Selected for resistance to: ChEBI; CHEBI:90225; Rubitecan (Orathecin; 9-nitrocamptothecin; 9NC).
Derived from sampling site: Pleural effusion.
Sequence variations PICALM-MLLT10 (CALM-AF10) gene fusion (from parent cell line).
Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (from parent cell line).
TOP1 p.Asp533Asn (c.1597G>A) (PubMed=9371509).
Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59); splice donor mutation (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line

Saleem A., Ibrahim N., Patel M., Li X.G., Gupta E., Mendoza J., Pantazis P., Rubin E.H.
Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning.
Cancer Res. 57:5100-5106(1997)

Entry history
Entry creation05-Jul-2019
Last entry update02-Jul-2020
Version number2