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Cellosaurus 786-OR (CVCL_WV95)

[Text version]

Cell line name 786-OR
Accession CVCL_WV95
Resource Identification Initiative To cite this cell line use: 786-OR (RRID:CVCL_WV95)
Comments Selected for resistance to: ChEBI; CHEBI:68478; Everolimus (RAD001).
Sequence variations Homozygous for PTEN p.Gln149Ter (c.445C>T) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Heterozygous for TP53 c.560-2A>G; splice acceptor mutation and p.Pro278Ala (c.832C>G) (ClinVar=VCV000376645) (from parent cell line).
Homozygous for VHL p.Gly104fs*55 (c.311delG) (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1051 (786-O)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line

PubMed=31267758; DOI=10.2217/fon-2019-0067
Nogueira I., Dias F., Morais M., Teixeira A.L., Medeiros R.
Everolimus resistance in clear cell renal cell carcinoma: miRNA-101 and HIF-2alpha as molecular triggers?
Future Oncol. 15:2361-2370(2019)

Other Wikidata; Q93309883
Entry history
Entry creation06-Sep-2019
Last entry update02-Jul-2020
Version number2