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Cellosaurus PA-JEB (CVCL_WW22)

Cell line name PA-JEB
Accession CVCL_WW22
Resource Identification Initiative To cite this cell line use: PA-JEB (RRID:CVCL_WW22)
Comments Doubling time: ~36 hours (PubMed=9660880).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Disease Epidermolysis bullosa, junctional, with pyloric atresia (NCIt: C162474)
Junctional epidermolysis bullosa-pyloric atresia syndrome (ORDO: Orphanet_79403)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WW23 (PA-JEB/beta4)CVCL_WW24 (PA-JEB/beta4-EGFP)
Sex of cell Sex unspecified
Age at sampling 5D
Category Transformed cell line
Publications

PubMed=8832392; DOI=10.1242/jcs.109.7.1695
Niessen C.M., van der Raaij-Helmer L.M.H., Hulsman E.H.M., van der Neut R., Jonkman M.F., Sonnenberg A.
Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties.
J. Cell Sci. 109:1695-1706(1996)

PubMed=9660880; DOI=10.1083/jcb.142.1.271
Schaapveld R.Q.J., Borradori L., Geerts D., van Leusden M.R., Kuikman I., Nievers M.G., Niessen C.M., Steenbergen R.D.M., Snijders P.J.F., Sonnenberg A.
Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180.
J. Cell Biol. 142:271-284(1998)

PubMed=10811835; DOI=10.1083/jcb.149.4.969
Sterk L.M.T., Geuijen C.A.W., Oomen L.C.J.M., Calafat J., Janssen H., Sonnenberg A.
The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.
J. Cell Biol. 149:969-982(2000)

PubMed=12429829; DOI=10.1091/mbc.02-01-0601
Geuijen C.A.W., Sonnenberg A.
Dynamics of the alpha6beta4 integrin in keratinocytes.
Mol. Biol. Cell 13:3845-3858(2002)

Cross-references
Encyclopedic resources Wikidata; Q98128425
Entry history
Entry creation06-Sep-2019
Last entry update21-Mar-2023
Version number4