Cellosaurus logo
expasy logo

Cellosaurus ERC-31(A) (CVCL_WX03)

[Text version]
Cell line name ERC-31(A)
Synonyms ERC31; Eker Renal Carcinoma-31
Accession CVCL_WX03
Resource Identification Initiative To cite this cell line use: ERC-31(A) (RRID:CVCL_WX03)
Comments Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; RGD; 3205; Nras; Simple; p.Gly13Val (c.38_39GC>TT); Zygosity=Unspecified (inferred from genetic background of other Eker-derived cell lines).
  • Mutation; RGD; 3205; Nras; Simple; p.Val14Ile (c.40G>A); Zygosity=Unspecified (inferred from genetic background of other Eker-derived cell lines).
  • Mutation; RGD; 3205; Nras; Simple; p.Ala18Val (c.53C>T); Zygosity=Unspecified (inferred from genetic background of other Eker-derived cell lines).
  • Mutation; RGD; 3908; Tsc2; Simple; p.Val1272fs; Zygosity=Heterozygous; Note=Insertion of a 5 kb retrotransposon (inferred from genetic background of other Eker-derived cell lines).
Disease Carcinoma of the rat kidney (NCIt: C64111)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Eker x Long-Evans.
Sex of cell Sex unspecified
Age at sampling 10-11M
Category Cancer cell line
Publications

CLPUB00521
Freed J.J., Howard S., Lerro A., Dodson L., Scsok D., Knudson A.G. Jr.
Hereditary renal tumors in the rat: cell lines from adenocarcinomas induced by the Eker mutation.
Proc. Am. Assoc. Cancer Res. 31:317-317(1990)

PubMed=8419937; DOI=10.1073/pnas.90.1.327
Hino O., Klein-Szanto A.J.P., Freed J.J., Testa J.R., Brown D.Q., Vilensky M., Yeung R.S.W., Tartof K.D., Knudson A.G. Jr.
Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.
Proc. Natl. Acad. Sci. U.S.A. 90:327-331(1993)

PubMed=7704028; DOI=10.1038/ng0195-70
Kobayashi T., Hirayama Y., Kobayashi E., Kubo Y., Hino O.
A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer.
Nat. Genet. 9:70-74(1995)

Cross-references
Encyclopedic resources Wikidata; Q93541748
Entry history
Entry creation06-Sep-2019
Last entry update29-Jun-2023
Version number7