Cellosaurus cell line Lk9dR (CVCL_WX08)

• Mutation; RGD; 3908; Tsc2; Simple; p.Val1272fs; Zygosity=Heterozygous; Note=Insertion of a 5 kb retrotransposon (PubMed=7704028).
  

PubMed=7559744; DOI=10.1007/BF01197777
Hino O., Kobayashi E., Nishizawa M., Kubo Y., Kobayashi T., Hirayama Y., Takai S., Kikuchi Y., Tsuchiya H., Orimoto K., Kajino K., Takahara T.
Renal carcinogenesis in the Eker rat.
J. Cancer Res. Clin. Oncol. 121:602-605(1995)

PubMed=7704028; DOI=10.1038/ng0195-70
Kobayashi T., Hirayama Y., Kobayashi E., Kubo Y., Hino O.
A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer.
Nat. Genet. 9:70-74(1995)

PubMed=11011112; DOI=10.1111/j.1349-7006.2000.tb01027.x
Majima S., Kajino K., Fukuda T., Otsuka F., Hino O.
A novel gene 'Niban' upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.
Jpn. J. Cancer Res. 91:869-874(2000)

PubMed=11115552; DOI=10.3892/ijo.18.1.147
Okamoto T., Momose S., Hino O.
Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats.
Int. J. Oncol. 18:147-149(2001)