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Cellosaurus VCaP-SL (CVCL_WZ27)

[Text version]

Cell line name VCaP-SL
Synonyms Stem-Like VCaP; VCaP-Stem Like
Accession CVCL_WZ27
Resource Identification Initiative To cite this cell line use: VCaP-SL (RRID:CVCL_WZ27)
Comments Population: Caucasian.
Characteristics: Reprogrammed to, maintained and propagated as cancer stem-like cells (CSCs) by growth in androgen-free neural/neural crest (N/NC) stem medium.
Omics: Transcriptome analysis.
Sequence variations
  • Gene fusion; HGNC; 3446; ERG + HGNC; 11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
  • Mutation; HGNC; 7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Bone; vertebra.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2235 (VCaP)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=28145883; DOI=10.18632/oncotarget.14850
Nouri M., Caradec J., Lubik A.A., Li N., Hollier B.G., Takhar M., Altimirano-Dimas M., Chen M., Roshan-Moniri M., Butler M., Lehman M., Bishop J., Truong S., Huang S.-C., Cochrane D., Cox M., Collins C., Gleave M., Erho N., Alshalafa M., Davicioni E., Nelson C., Gregory-Evans S., Karnes R.J., Jenkins R.B., Klein E.A., Buttyan R.
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Oncotarget 8:18949-18967(2017)

Cross-references
Encyclopedic resources Wikidata; Q98134496
Gene expression databases GEO; GSM1633314
GEO; GSM1633315
GEO; GSM1633316
Entry history
Entry creation06-Sep-2019
Last entry update23-Sep-2021
Version number7