ID   H69/Txl
AC   CVCL_X029
DR   cancercelllines; CVCL_X029
DR   Wikidata; Q54872202
RX   PubMed=7514586;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1579 ! NCI-H69
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 05-10-23; Version: 16
//
RX   PubMed=7514586; DOI=10.1111/j.1349-7006.1994.tb02096.x;
RA   Ohta S., Nishio K., Kubota N., Ohmori T., Funayama Y., Ohira T.,
RA   Nakajima H., Adachi M., Saijo N.;
RT   "Characterization of a taxol-resistant human small-cell lung cancer
RT   cell line.";
RL   Jpn. J. Cancer Res. 85:290-297(1994).
//