Cellosaurus cell line V-C8 (CVCL_X405)

• Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  
• Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
  

PubMed=3587254; DOI=10.1016/0027-5107(87)90274-0
Zdzienicka M.Z., Simons J.W.I.M.
Mutagen-sensitive cell lines are obtained with a high frequency in V79 Chinese hamster cells.
Mutat. Res. 178:235-244(1987)

PubMed=7565860; DOI=10.1016/0921-8777(95)00017-E
Verhaegh G.W.C.T., Jongmans W., Morolli B., Jaspers N.G.J., van der Schans G.P., Lohman P.H.M., Zdzienicka M.Z.
A novel type of X-ray-sensitive Chinese hamster cell mutant with radioresistant DNA synthesis and hampered DNA double-strand break repair.
Mutat. Res. 337:119-129(1995)

PubMed=11756561; DOI=10.1128/mcb.22.2.669-679.2002
Kraakman-van der Zwet M., Overkamp W.J.I., van Lange R.E.E., Essers J., van Duijn-Goedhart A., Wiggers I., Swaminathan S., van Buul P.P.W., Errami A., Tan R.T.L., Jaspers N.G.J., Sharan S.K., Kanaar R., Zdzienicka M.Z.
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.
Mol. Cell. Biol. 22:669-679(2002)

PubMed=16643964; DOI=10.1016/j.mrfmmm.2006.03.001
Wiegant W.W., Overmeer R.M., Godthelp B.C., van Buul P.P.W., Zdzienicka M.Z.
Chinese hamster cell mutant, V-C8, a model for analysis of Brca2 function.
Mutat. Res. 600:79-88(2006)