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Cellosaurus 201T (CVCL_X481)

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Cell line name 201T
Accession CVCL_X481
Resource Identification Initiative To cite this cell line use: 201T (RRID:CVCL_X481)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
From: Siegfried J.M.; University of Pittsburgh; Pittsburgh; USA.
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Miscellaneous: Age of donor from personal communication of Siegfried J.M.
Derived from sampling site: Lung.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Ser241Ala (c.721T>G); ClinVar=VCV000376665; Zygosity=Homozygous (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North2.58
East Asian, South0
South Asian0
European, North3.06
European, South5.55
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP


Run an STR similarity search on this cell line

Kasprzyk P.G., Sullivan T.L., Hunt J.D., Gubish C.T., Scoppa C.A., Oelkuct M., Bird R., Fischer P.H., Siegfried J.M., King C.R.
Activity of anti-erbB-2 recombinant toxin OLX-209 on lung cancer cell lines in the absence of erbB-2 gene amplification.
Clin. Cancer Res. 2:75-80(1996)

Skrepnik N., Araya J.C., Qian Z., Xu H., Hamide J., Mera R., Hunt J.D.
Effects of anti-erbB-2 (HER-2/neu) recombinant oncotoxin AR209 on human non-small cell lung carcinoma grown orthotopically in athymic nude mice.
Clin. Cancer Res. 2:1851-1857(1996)

PubMed=10545285; DOI=10.1006/pupt.1999.0210
Siegfried J.M., Krishnamachary N., Gaither Davis A., Gubish C., Hunt J.D., Shriver S.P.
Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer.
Pulm. Pharmacol. Ther. 12:291-302(1999)

PubMed=15735034; DOI=10.1158/0008-5472.CAN-04-1872
Stabile L.P., Lyker J.S., Gubish C.T., Zhang W., Grandis J.R., Siegfried J.M.
Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects.
Cancer Res. 65:1459-1470(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line databases/resources CCLE; 201T_LUNG
Cell_Model_Passport; SIDM00055
Cosmic-CLP; 1287381
DepMap; ACH-002089
Chemistry resources GDSC; 1287381
PharmacoDB; 201T_7_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827492
GEO; GSM1669564
Other Wikidata; Q54583071
Polymorphism and mutation databases Cosmic; 910550
Progenetix; CVCL_X481
Entry history
Entry creation05-Sep-2014
Last entry update20-May-2021
Version number16