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Cellosaurus EMC-BAC-1 (CVCL_X486)

[Text version]

Cell line name EMC-BAC-1
Synonyms EMCBAC1
Accession CVCL_X486
Resource Identification Initiative To cite this cell line use: EMC-BAC-1 (RRID:CVCL_X486)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations
  • Mutation; HGNC; 11389; STK11; Simple; p.Glu165Ter (c.493G>T) (c.637C>T); Zygosity=Homozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Homozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African74.47
Native American0
East Asian, North2.69
East Asian, South12.82
South Asian0
European, North3.5
European, South6.52
Disease Lung non-small cell carcinoma (NCIt: C2926)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81810,12
D7S82010
D13S31711
D16S53910,12
TH017
TPOX10
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM00048
Cosmic-CLP; 1503369
DepMap; ACH-002101
Chemistry resources GDSC; 1503369
PharmacoDB; EMCBAC1_332_2019
Encyclopedic resources Wikidata; Q54832279
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669763
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation05-Sep-2014
Last entry update16-Dec-2021
Version number15