| Cell line name |
U-2946 |
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| Accession |
CVCL_X503 |
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| Resource Identification Initiative |
To cite this cell line use: U-2946 (RRID:CVCL_X503) |
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| Comments |
Part of: LL-100 blood cancer cell line panel.
Doubling time: 48 hours (PubMed=27907212); ~20-30 hours (DSMZ=ACC-795).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (PubMed=31160637).
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| HLA typing |
Source: DSMZCellDive=ACC-795
| Class I | | HLA-A | A*01:01:01,02:01:01 | | HLA-B | B*35:01:01,52:01:01 | | HLA-C | C*04:01:01,12:02:02 | | Class II | | HLA-DP | DPA1*01:03:01,01:03:01 | | DPB1*04:02:01,02:01:02 | | HLA-DQ | DQA1*01:03:01,01:01:01 | | DQB1*05:01:01,06:01:01 | | HLA-DR | DRA*01:01:01,01:02:02 | | DRB1*01:01:01,15:02:01 |
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| Disease |
Diffuse large B-cell lymphoma activated B-cell type (NCIt: C36081)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Sex of cell |
Male |
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| Age at sampling |
52Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): DSMZ
Markers:| Amelogenin | X,Y |
| CSF1PO | 10,11 |
| D2S1338 | 20,24 |
| D3S1358 | 15,16 |
| D5S818 | 11,12 |
| D7S820 | 8,10 |
| D8S1179 | 10,14 |
| D13S317 | 11,12 |
| D16S539 | 11,12 |
| D18S51 | 11,17 |
| D19S433 | 12 |
| D21S11 | 30 |
| FGA | 20,23 |
| Penta D | 9 |
| Penta E | 11 |
| TH01 | 6,9.3 |
| TPOX | 9,12 |
| vWA | 17,18 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=17926183; DOI=10.1080/10428190701636443
Fridberg M., Servin A., Anagnostaki L., Linderoth J., Berglund M., Soderberg O., Enblad G., Rosen A., Mustelin T., Jerkeman M., Persson J.L., Wingren A.G.
Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.
Leuk. Lymphoma 48:2221-2232(2007) PubMed=27907212; DOI=10.1371/journal.pone.0167599
Quentmeier H., Drexler H.G., Hauer V., MacLeod R.A.F., Pommerenke C., Uphoff C.C., Zaborski M., Berglund M., Enblad G., Amini R.-M.
Diffuse large B cell lymphoma cell line U-2946: model for MCL1 inhibitor testing.
PLoS ONE 11:E0167599-E0167599(2016) PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019) |
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| Cross-references |
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| Cell line collections (Providers) |
DSMZ; ACC-795
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| Cell line databases/resources |
DSMZCellDive; ACC-795
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| Encyclopedic resources |
Wikidata; Q54973562
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| Gene expression databases |
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
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| Entry history |
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| Entry creation | 05-Sep-2014 |
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| Last entry update | 29-Jun-2023 |
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| Version number | 16 |
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