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Cellosaurus T78-1 (CVCL_X527)

[Text version]
Cell line name T78-1
Synonyms V79puro
Accession CVCL_X527
Resource Identification Initiative To cite this cell line use: T78-1 (RRID:CVCL_X527)
Comments Transfected with: UniProtKB; P38489; Escherichia coli nitroreductase nfnB.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_2234 (V79)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=9111301; DOI=10.1021/jm960794l
Friedlos F., Denny W.A., Palmer B.D., Springer C.J.
Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy.
J. Med. Chem. 40:1270-1275(1997)

PubMed=14997211; DOI=10.1038/sj.bjc.6601612
Helsby N.A., Ferry D.M., Patterson A.V., Pullen S.M., Wilson W.R.
2-amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.
Br. J. Cancer 90:1084-1092(2004)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL3307256
ChEMBL-Targets; CHEMBL613095
PubChem_Cell_line; CVCL_X527
Encyclopedic resources Wikidata; Q54971618
Entry history
Entry creation05-Sep-2014
Last entry update29-Jun-2023
Version number13