Home  |  Contact

Cellosaurus THP1-Blue NF-kappaB (CVCL_X585)

[Text version]

Cell line name THP1-Blue NF-kappaB
Accession CVCL_X585
Resource Identification Initiative To cite this cell line use: THP1-Blue NF-kappaB (RRID:CVCL_X585)
Comments Population: Japanese.
Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 copies of the NF-kappaB consensus TRE and 3 copies of the c-Rel binding site.
Transfected with: HGNC; 439; ALPP.
Transfected with: UniProtKB; P33967; B.cereus Bsr.
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Children:
CVCL_A8CC (THP1-Blue KI-IP10)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages https://www.invivogen.com/thp1-blue-nfkb
Publications

PubMed=25130606; DOI=10.1016/j.intimp.2014.08.002
Chanput W., Mes J.J., Wichers H.J.
THP-1 cell line: an in vitro cell model for immune modulation approach.
Int. Immunopharmacol. 23:37-45(2014)

Cross-references
Other Wikidata; Q54972362
Entry history
Entry creation05-Sep-2014
Last entry update20-May-2021
Version number12