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Cellosaurus THP1-Lucia ISG (CVCL_X587)

[Text version]

Cell line name THP1-Lucia ISG
Accession CVCL_X587
Resource Identification Initiative To cite this cell line use: THP1-Lucia ISG (RRID:CVCL_X587)
Comments Population: Japanese.
Characteristics: The Lucia luciferase gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE).
Transfected with: Lucia luciferase; a synthetic gene designed on natural secreted luciferase genes from marine copepods.
Transfected with: UniProtKB; P17493; S.hindustanus ble.
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages https://www.invivogen.com/thp1-lucia-isg
Other Wikidata; Q54972370
Entry history
Entry creation05-Sep-2014
Last entry update20-May-2021
Version number10