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Cellosaurus THP1-Dual (CVCL_X599)

[Text version]

Cell line name THP1-Dual
Accession CVCL_X599
Resource Identification Initiative To cite this cell line use: THP1-Dual (RRID:CVCL_X599)
Comments Population: Japanese.
Characteristics: Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE).
Transfected with: HGNC; 439; ALPP.
Transfected with: Lucia luciferase; a synthetic gene designed on natural secreted luciferase genes from marine copepods.
Transfected with: UniProtKB; P17493; S.hindustanus ble.
Transfected with: UniProtKB; P33967; B.cereus Bsr.
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Children:
CVCL_A8AI (THP1-Dual KO-cGAS)CVCL_A8AU (THP1-Dual KO-IFI16)CVCL_A8AL (THP1-Dual KO-IFNAR2)
CVCL_A8AZ (THP1-Dual KO-IKKepsilon)CVCL_A8AV (THP1-Dual KO-IRF3)CVCL_A8BA (THP1-Dual KO-MAVS)
CVCL_A8BB (THP1-Dual KO-MDA5)CVCL_5J54 (THP1-Dual KO-MyD)CVCL_A8BC (THP1-Dual KO-RIG-I)
CVCL_A8AH (THP1-Dual KO-STING)CVCL_A8AY (THP1-Dual KO-TBK1)CVCL_A8AW (THP1-Dual KO-TLR2)
CVCL_A8AX (THP1-Dual KO-TLR4)CVCL_A8BW (THP1-Dual KO-TLR8)CVCL_A8AJ (THP1-Dual KO-TREX1)
CVCL_A8AM (THP1-Dual KO-TRIF)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages https://www.invivogen.com/thp1-dual
Cross-references
Other Wikidata; Q54972368
Entry history
Entry creation05-Sep-2014
Last entry update20-May-2021
Version number10