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Cellosaurus THP1-Null (CVCL_X601)

[Text version]

Cell line name THP1-Null
Accession CVCL_X601
Resource Identification Initiative To cite this cell line use: THP1-Null (RRID:CVCL_X601)
Comments Population: Japanese.
Transfected with: UniProtKB; P00557; E.coli hygromycin-B 4-O-kinase (hph).
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
CVCL_X598 (THP1-defASC)CVCL_5I76 (THP1-defCASP1)CVCL_X600 (THP1-defNLRP3)
CVCL_A8BZ (THP1-Difluo hLC3)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages https://www.invivogen.com/thp1-null
Other Wikidata; Q54972374
Entry history
Entry creation05-Sep-2014
Last entry update20-May-2021
Version number10